| Academy Award Nominations and Winners: |
| Best Picture |
| ★ | Best Director: Steven Soderbergh |
| ★ | Best Supporting Actor: Benicio Del Toro |
| ★ | Best Adapted Screenplay: Stephen Gaghan |
| ★ | Best Film Editing: Stephen Mirrione |
|
| Golden Globe Nominations and Winners: |
| Best Picture (Drama) |
| Best Director: Steven Soderbergh |
| Best Supporting Actress: Catherine Zeta-Jones |
| ★ | Best Supporting Actor: Benicio Del Toro |
| ★ | Best Screenplay: Stephen Gaghan |
|
| Other Awards: |
| Berlin Film Festival: Best Actor (Del Toro) |
| Screen Actors Guild Awards: Best Supporting Actor (Del Toro); Best Ensemble Cast |
| Writers Guild of America: Best Adapted Screenplay |
| New York Film Critics Circle: Best Picture; Best Director (also cited for Erin Brockovich); Best Supporting Actor (Del Toro) |
| Los Angeles Film Critics Association: Best Director (also cited for Erin Brockovich) |
| National Society of Film Critics: Best Director (also cited for Erin Brockovich); Best Supporting Actor (Del Toro) |
| National Board of Review: Best Director (also cited for Erin Brockovich) |
| British Academy Awards (BAFTAs): Best Supporting Actor (Del Toro); Best Adapted Screenplay |
| Satellite Awards: Best Picture (Drama); Best Director; Best Ensemble Cast |